Multifactorial Analysis of Differences Between Sporadic Breast Cancers and Cancers Involving BRCA1 and BRCA2 Mutations
Identifieur interne : 00C903 ( Main/Exploration ); précédent : 00C902; suivant : 00C904Multifactorial Analysis of Differences Between Sporadic Breast Cancers and Cancers Involving BRCA1 and BRCA2 Mutations
Auteurs : Sunil R. Lakhani [Royaume-Uni] ; Jocelyne Jacquemier [France] ; John P. Sloane [Royaume-Uni] ; Barry A. Gusterson [Royaume-Uni] ; Thomas J. Anderson [Royaume-Uni] ; Marc J. Van De Vijver [Pays-Bas] ; Linda M. Farid ; Deon Venter [Australie] ; Antonios Antoniou [Royaume-Uni] ; Amy Storfer-Isser [Royaume-Uni] ; Elizabeth Smyth [Royaume-Uni] ; C. Michael Steel [Royaume-Uni] ; Neva Haites [Royaume-Uni] ; Rodney J. Scott [Suisse] ; David Goldgar [France] ; Susan Neuhausen ; Peter A. Daly [Irlande (pays)] ; Wilma Ormiston [Irlande (pays)] ; Ross Mcmanus [Irlande (pays)] ; Siegfried Scherneck [Allemagne] ; Bruce A. J. Ponder [Royaume-Uni] ; Debbie Ford [Royaume-Uni] ; Julian Peto [Royaume-Uni] ; Dominique Stoppa-Lyonnet [France] ; Yves-Jean Bignon ; Jeffery P. Struewing [États-Unis] ; Nigel K. Spurr [Royaume-Uni] ; D. Timothy Bishop [Royaume-Uni] ; J. G. M. Klijn [Pays-Bas] ; Peter Devilee [Pays-Bas] ; Cees J. Cornelisse [Pays-Bas] ; Christine Lasset [France] ; Gilbert Lenoir ; Rosa Bjork Barkardottir ; Valgardur Egilsson ; Ute Hamann [Allemagne] ; Jenny Chang-Claude [Allemagne] ; Hagay Sobol [France] ; Barbara Weber [États-Unis] ; Michael R. Stratton [Royaume-Uni] ; Douglas F. Easton [Royaume-Uni]Source :
- Journal of the National Cancer Institute [ 0027-8874 ] ; 1998-08-05.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Background: We have previously demonstrated that breast cancers associated with inherited BRCA1 and BRCA2 gene mutations differ from each other in their histopathologic appearances and that each of these types differs from breast cancers in patients unselected for family history (i.e., sporadic cancers). We have now conducted a more detailed examination of cytologic and architectural features of these tumors. Methods: Specimens of tumor tissue (5-µm-thick sections) were examined independently by two pathologists, who were unaware of the case or control subject status, for the presence of cell mitosis, lymphocytic infiltration, continuous pushing margins, and solid sheets of cancer cells; cell nuclei, cell nucleoli, cell necrosis, and cell borders were also evaluated. The resulting data were combined with previously available information on tumor type and tumor grade and further evaluated by multifactorial analysis. All statistical tests are two-sided. Results: Cancers associated with BRCA1 mutations exhibited higher mitotic counts (P = .001), a greater proportion of the tumor with a continuous pushing margin (P<.0001), and more lymphocytic infiltration (P = .002) than sporadic (i.e., control) cancers. Cancers associated with BRCA2 mutations exhibited a higher score for tubule formation (fewer tubules) (P = .0002), a higher proportion of the tumor perimeter with a continuous pushing margin (P<.0001), and a lower mitotic count (P = .003) than control cancers. Conclusions: Our study has identified key features of the histologic phenotypes of breast cancers in carriers of mutant BRCA1 and BRCA2 genes. This information may improve the classification of breast cancers in individuals with a family history of the disease and may ultimately aid in the clinical management of patients. [J Natl Cancer Inst 1998;90:1138–45]
Url:
DOI: 10.1093/jnci/90.15.1138
Affiliations:
- Allemagne, Australie, France, Irlande (pays), Pays-Bas, Royaume-Uni, Suisse, États-Unis
- Angleterre, Angleterre de l'Est, Auvergne-Rhône-Alpes, Bade-Wurtemberg, Berlin, District de Karlsruhe, Hollande-Méridionale, Hollande-Septentrionale, Maryland, Pennsylvanie, Provence-Alpes-Côte d'Azur, Rhône-Alpes, Victoria (État), Écosse, Île-de-France
- Amsterdam, Berlin, Cambridge, Heidelberg, Lyon, Marseille, Melbourne, Paris, Philadelphie, Rotterdam, Édimbourg
- Université de Cambridge, Université de Melbourne
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Michael" last="Steel">C. Michael Steel</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>School of Biological and Medical Sciences, University of St. Andrews, Fife</wicri:regionArea><wicri:noRegion>Fife</wicri:noRegion></affiliation></author><author><name sortKey="Haites, Neva" sort="Haites, Neva" uniqKey="Haites N" first="Neva" last="Haites">Neva Haites</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Medical Genetics, Department of Medicine and Therapeutics, University of Aberdeen</wicri:regionArea><wicri:noRegion>University of Aberdeen</wicri:noRegion></affiliation></author><author><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name><affiliation wicri:level="1"><country xml:lang="fr">Suisse</country><wicri:regionArea>Humangenetik, Department Forschung, Kantonsspital, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Goldgar, David" sort="Goldgar, David" uniqKey="Goldgar D" first="David" last="Goldgar">David Goldgar</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Neuhausen, Susan" sort="Neuhausen, Susan" uniqKey="Neuhausen S" first="Susan" last="Neuhausen">Susan Neuhausen</name><affiliation><wicri:noCountry code="subField">City</wicri:noCountry></affiliation></author><author><name sortKey="Daly, Peter A" sort="Daly, Peter A" uniqKey="Daly P" first="Peter A." last="Daly">Peter A. Daly</name><affiliation wicri:level="1"><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Medicine, Trinity College Medical School, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Ormiston, Wilma" sort="Ormiston, Wilma" uniqKey="Ormiston W" first="Wilma" last="Ormiston">Wilma Ormiston</name><affiliation wicri:level="1"><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Medicine, Trinity College Medical School, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Mcmanus, Ross" sort="Mcmanus, Ross" uniqKey="Mcmanus R" first="Ross" last="Mcmanus">Ross Mcmanus</name><affiliation wicri:level="1"><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea>Department of Medicine, Trinity College Medical School, Dublin</wicri:regionArea><wicri:noRegion>Dublin</wicri:noRegion></affiliation></author><author><name sortKey="Scherneck, Siegfried" sort="Scherneck, Siegfried" uniqKey="Scherneck S" first="Siegfried" last="Scherneck">Siegfried Scherneck</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max-Delbruck-Centrum fur Moleculare Medizin, Tumorgenetik, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Ponder, Bruce A J" sort="Ponder, Bruce A J" uniqKey="Ponder B" first="Bruce A. J." last="Ponder">Bruce A. J. Ponder</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research Campaign Human Cancer Genetics Research Group, Level 3, Laboratories Block, Addenbrookes Hospital, Cambridge</wicri:regionArea><wicri:noRegion>Cambridge</wicri:noRegion></affiliation></author><author><name sortKey="Ford, Debbie" sort="Ford, Debbie" uniqKey="Ford D" first="Debbie" last="Ford">Debbie Ford</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sections of Cancer Genetics, Epidemiology, and Cell Biology and Experimental Pathology, Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sections of Cancer Genetics, Epidemiology, and Cell Biology and Experimental Pathology, Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Unité de Genetique Oncologique, Institut Curie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Bignon, Yves Jean" sort="Bignon, Yves Jean" uniqKey="Bignon Y" first="Yves-Jean" last="Bignon">Yves-Jean Bignon</name></author><author><name sortKey="Struewing, Jeffery P" sort="Struewing, Jeffery P" uniqKey="Struewing J" first="Jeffery P." last="Struewing">Jeffery P. Struewing</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics,National Cancer Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Spurr, Nigel K" sort="Spurr, Nigel K" uniqKey="Spurr N" first="Nigel K." last="Spurr">Nigel K. Spurr</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Molecular Genetics, Imperial Cancer Research Fund, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Bishop, D Timothy" sort="Bishop, D Timothy" uniqKey="Bishop D" first="D. Timothy" last="Bishop">D. Timothy Bishop</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Imperial Cancer Research Fund Genetic Epidemiology Laboratory, St. James University Hospital, Leeds</wicri:regionArea><wicri:noRegion>Leeds</wicri:noRegion></affiliation></author><author><name sortKey="Klijn, J G M" sort="Klijn, J G M" uniqKey="Klijn J" first="J. G. M." last="Klijn">J. G. M. Klijn</name><affiliation wicri:level="3"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Daniel den Hoed Cancer Centre, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Genetics and Pathology, Leiden University</wicri:regionArea><wicri:noRegion>Leiden University</wicri:noRegion></affiliation></author><author><name sortKey="Cornelisse, Cees J" sort="Cornelisse, Cees J" uniqKey="Cornelisse C" first="Cees J." last="Cornelisse">Cees J. Cornelisse</name><affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Genetics and Pathology, Leiden University</wicri:regionArea><wicri:noRegion>Leiden University</wicri:noRegion></affiliation></author><author><name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Centre Leon Bernard, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Lenoir, Gilbert" sort="Lenoir, Gilbert" uniqKey="Lenoir G" first="Gilbert" last="Lenoir">Gilbert Lenoir</name></author><author><name sortKey="Barkardottir, Rosa Bjork" sort="Barkardottir, Rosa Bjork" uniqKey="Barkardottir R" first="Rosa Bjork" last="Barkardottir">Rosa Bjork Barkardottir</name><affiliation><wicri:noCountry code="subField">Reykjavik</wicri:noCountry></affiliation></author><author><name sortKey="Egilsson, Valgardur" sort="Egilsson, Valgardur" uniqKey="Egilsson V" first="Valgardur" last="Egilsson">Valgardur Egilsson</name><affiliation><wicri:noCountry code="subField">Reykjavik</wicri:noCountry></affiliation></author><author><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Epidemiology and Molecular Genome Analysis, Deutsches Krebsforschungszentrum, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Epidemiology and Molecular Genome Analysis, Deutsches Krebsforschungszentrum, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Sobol, Hagay" sort="Sobol, Hagay" uniqKey="Sobol H" first="Hagay" last="Sobol">Hagay Sobol</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Departement d'Oncologie-Genetique et Laboratoire d'Anatomie et de Cytologie Pathologiques, Institut National de la Santé et de la Recherche Médicale CRI 9703, Institut Paoli-Calmettes, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Weber, Barbara" sort="Weber, Barbara" uniqKey="Weber B" first="Barbara" last="Weber">Barbara Weber</name><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Philadelphie</settlement><region type="state">Pennsylvanie</region></placeName><wicri:orgArea>University of Pennsylvania Cancer Center</wicri:orgArea></affiliation></author><author><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sections of Cancer Genetics, Epidemiology, and Cell Biology and Experimental Pathology, Institute of Cancer Research, Haddow Laboratories, Sutton, Surrey</wicri:regionArea><wicri:noRegion>Surrey</wicri:noRegion></affiliation></author><author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Cancer Research Campaign Genetic Epidemiology Group, Department of Community Medicine, Institute of Public Health, University of Cambridge</wicri:regionArea><placeName><settlement type="city">Cambridge</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Angleterre de l'Est</region></placeName><orgName type="university">Université de Cambridge</orgName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the National Cancer Institute</title><title level="j" type="abbrev">Journal of the National Cancer Institute</title><idno type="ISSN">0027-8874</idno><idno type="eISSN">1460-2105</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1998-08-05">1998-08-05</date><biblScope unit="volume">90</biblScope><biblScope unit="issue">15</biblScope><biblScope unit="page" from="1138">1138</biblScope><biblScope unit="page" to="1145">1145</biblScope></imprint><idno type="ISSN">0027-8874</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0027-8874</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>C-Onc gene</term><term>Carcinoma</term><term>Differential diagnostic</term><term>Familial cancer</term><term>Female</term><term>Human</term><term>Mammary gland</term><term>Morphology</term><term>Mutation</term><term>Pathology</term><term>Protooncogene</term><term>Sporadic</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Anatomopathologie</term><term>Cancer familial</term><term>Carcinome</term><term>Diagnostic différentiel</term><term>Femelle</term><term>Glande mammaire</term><term>Gène BRCA1</term><term>Gène BRCA2</term><term>Gène onc cellulaire</term><term>Homme</term><term>Morphologie</term><term>Mutation</term><term>Protooncogène</term><term>Sporadique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Background: We have previously demonstrated that breast cancers associated with inherited BRCA1 and BRCA2 gene mutations differ from each other in their histopathologic appearances and that each of these types differs from breast cancers in patients unselected for family history (i.e., sporadic cancers). We have now conducted a more detailed examination of cytologic and architectural features of these tumors. Methods: Specimens of tumor tissue (5-µm-thick sections) were examined independently by two pathologists, who were unaware of the case or control subject status, for the presence of cell mitosis, lymphocytic infiltration, continuous pushing margins, and solid sheets of cancer cells; cell nuclei, cell nucleoli, cell necrosis, and cell borders were also evaluated. The resulting data were combined with previously available information on tumor type and tumor grade and further evaluated by multifactorial analysis. All statistical tests are two-sided. Results: Cancers associated with BRCA1 mutations exhibited higher mitotic counts (P = .001), a greater proportion of the tumor with a continuous pushing margin (P<.0001), and more lymphocytic infiltration (P = .002) than sporadic (i.e., control) cancers. Cancers associated with BRCA2 mutations exhibited a higher score for tubule formation (fewer tubules) (P = .0002), a higher proportion of the tumor perimeter with a continuous pushing margin (P<.0001), and a lower mitotic count (P = .003) than control cancers. Conclusions: Our study has identified key features of the histologic phenotypes of breast cancers in carriers of mutant BRCA1 and BRCA2 genes. This information may improve the classification of breast cancers in individuals with a family history of the disease and may ultimately aid in the clinical management of patients. [J Natl Cancer Inst 1998;90:1138–45]</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>France</li><li>Irlande (pays)</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Angleterre de l'Est</li><li>Auvergne-Rhône-Alpes</li><li>Bade-Wurtemberg</li><li>Berlin</li><li>District de Karlsruhe</li><li>Hollande-Méridionale</li><li>Hollande-Septentrionale</li><li>Maryland</li><li>Pennsylvanie</li><li>Provence-Alpes-Côte d'Azur</li><li>Rhône-Alpes</li><li>Victoria (État)</li><li>Écosse</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Berlin</li><li>Cambridge</li><li>Heidelberg</li><li>Lyon</li><li>Marseille</li><li>Melbourne</li><li>Paris</li><li>Philadelphie</li><li>Rotterdam</li><li>Édimbourg</li></settlement><orgName><li>Université de Cambridge</li><li>Université de Melbourne</li></orgName></list><tree><noCountry><name sortKey="Barkardottir, Rosa Bjork" sort="Barkardottir, Rosa Bjork" uniqKey="Barkardottir R" first="Rosa Bjork" last="Barkardottir">Rosa Bjork Barkardottir</name><name sortKey="Bignon, Yves Jean" sort="Bignon, Yves Jean" uniqKey="Bignon Y" first="Yves-Jean" last="Bignon">Yves-Jean Bignon</name><name sortKey="Egilsson, Valgardur" sort="Egilsson, Valgardur" uniqKey="Egilsson V" first="Valgardur" last="Egilsson">Valgardur Egilsson</name><name sortKey="Farid, Linda M" sort="Farid, Linda M" uniqKey="Farid L" first="Linda M." last="Farid">Linda M. Farid</name><name sortKey="Lenoir, Gilbert" sort="Lenoir, Gilbert" uniqKey="Lenoir G" first="Gilbert" last="Lenoir">Gilbert Lenoir</name><name sortKey="Neuhausen, Susan" sort="Neuhausen, Susan" uniqKey="Neuhausen S" first="Susan" last="Neuhausen">Susan Neuhausen</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Lakhani, Sunil R" sort="Lakhani, Sunil R" uniqKey="Lakhani S" first="Sunil R." last="Lakhani">Sunil R. Lakhani</name></noRegion><name sortKey="Anderson, Thomas J" sort="Anderson, Thomas J" uniqKey="Anderson T" first="Thomas J." last="Anderson">Thomas J. Anderson</name><name sortKey="Antoniou, Antonios" sort="Antoniou, Antonios" uniqKey="Antoniou A" first="Antonios" last="Antoniou">Antonios Antoniou</name><name sortKey="Bishop, D Timothy" sort="Bishop, D Timothy" uniqKey="Bishop D" first="D. Timothy" last="Bishop">D. Timothy Bishop</name><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name><name sortKey="Ford, Debbie" sort="Ford, Debbie" uniqKey="Ford D" first="Debbie" last="Ford">Debbie Ford</name><name sortKey="Gusterson, Barry A" sort="Gusterson, Barry A" uniqKey="Gusterson B" first="Barry A." last="Gusterson">Barry A. Gusterson</name><name sortKey="Haites, Neva" sort="Haites, Neva" uniqKey="Haites N" first="Neva" last="Haites">Neva Haites</name><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name><name sortKey="Ponder, Bruce A J" sort="Ponder, Bruce A J" uniqKey="Ponder B" first="Bruce A. J." last="Ponder">Bruce A. J. Ponder</name><name sortKey="Sloane, John P" sort="Sloane, John P" uniqKey="Sloane J" first="John P." last="Sloane">John P. Sloane</name><name sortKey="Smyth, Elizabeth" sort="Smyth, Elizabeth" uniqKey="Smyth E" first="Elizabeth" last="Smyth">Elizabeth Smyth</name><name sortKey="Spurr, Nigel K" sort="Spurr, Nigel K" uniqKey="Spurr N" first="Nigel K." last="Spurr">Nigel K. Spurr</name><name sortKey="Steel, C Michael" sort="Steel, C Michael" uniqKey="Steel C" first="C. Michael" last="Steel">C. Michael Steel</name><name sortKey="Storfer Isser, Amy" sort="Storfer Isser, Amy" uniqKey="Storfer Isser A" first="Amy" last="Storfer-Isser">Amy Storfer-Isser</name><name sortKey="Stratton, Michael R" sort="Stratton, Michael R" uniqKey="Stratton M" first="Michael R." last="Stratton">Michael R. Stratton</name></country><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Jacquemier, Jocelyne" sort="Jacquemier, Jocelyne" uniqKey="Jacquemier J" first="Jocelyne" last="Jacquemier">Jocelyne Jacquemier</name></region><name sortKey="Goldgar, David" sort="Goldgar, David" uniqKey="Goldgar D" first="David" last="Goldgar">David Goldgar</name><name sortKey="Lasset, Christine" sort="Lasset, Christine" uniqKey="Lasset C" first="Christine" last="Lasset">Christine Lasset</name><name sortKey="Sobol, Hagay" sort="Sobol, Hagay" uniqKey="Sobol H" first="Hagay" last="Sobol">Hagay Sobol</name><name sortKey="Stoppa Lyonnet, Dominique" sort="Stoppa Lyonnet, Dominique" uniqKey="Stoppa Lyonnet D" first="Dominique" last="Stoppa-Lyonnet">Dominique Stoppa-Lyonnet</name></country><country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Van De Vijver, Marc J" sort="Van De Vijver, Marc J" uniqKey="Van De Vijver M" first="Marc J." last="Van De Vijver">Marc J. Van De Vijver</name></region><name sortKey="Cornelisse, Cees J" sort="Cornelisse, Cees J" uniqKey="Cornelisse C" first="Cees J." last="Cornelisse">Cees J. Cornelisse</name><name sortKey="Devilee, Peter" sort="Devilee, Peter" uniqKey="Devilee P" first="Peter" last="Devilee">Peter Devilee</name><name sortKey="Klijn, J G M" sort="Klijn, J G M" uniqKey="Klijn J" first="J. G. M." last="Klijn">J. G. M. Klijn</name></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Venter, Deon" sort="Venter, Deon" uniqKey="Venter D" first="Deon" last="Venter">Deon Venter</name></region></country><country name="Suisse"><noRegion><name sortKey="Scott, Rodney J" sort="Scott, Rodney J" uniqKey="Scott R" first="Rodney J." last="Scott">Rodney J. Scott</name></noRegion></country><country name="Irlande (pays)"><noRegion><name sortKey="Daly, Peter A" sort="Daly, Peter A" uniqKey="Daly P" first="Peter A." last="Daly">Peter A. Daly</name></noRegion><name sortKey="Mcmanus, Ross" sort="Mcmanus, Ross" uniqKey="Mcmanus R" first="Ross" last="Mcmanus">Ross Mcmanus</name><name sortKey="Ormiston, Wilma" sort="Ormiston, Wilma" uniqKey="Ormiston W" first="Wilma" last="Ormiston">Wilma Ormiston</name></country><country name="Allemagne"><region name="Berlin"><name sortKey="Scherneck, Siegfried" sort="Scherneck, Siegfried" uniqKey="Scherneck S" first="Siegfried" last="Scherneck">Siegfried Scherneck</name></region><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name><name sortKey="Hamann, Ute" sort="Hamann, Ute" uniqKey="Hamann U" first="Ute" last="Hamann">Ute Hamann</name></country><country name="États-Unis"><region name="Maryland"><name sortKey="Struewing, Jeffery P" sort="Struewing, Jeffery P" uniqKey="Struewing J" first="Jeffery P." last="Struewing">Jeffery P. Struewing</name></region><name sortKey="Weber, Barbara" sort="Weber, Barbara" uniqKey="Weber B" first="Barbara" last="Weber">Barbara Weber</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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